Geon Neurodegeneration: The Sites of Onset
Predicted by Wireless Communication Model

 

Abstract

According to the Wireless Communication Model proposed in Paper 1, the receiving neurons for electromagnetic (EM) waves should display subthreshold oscillations so that the EM waves can push the membrane potential above threshold to achieve large scale synchronization. These receiving neurons are vulnerable to hyperexcitability and thus could be the sites of onset for neurodegeneration. Based on this notion, the initial sites for major neurodegenerative disorders have been identified. Each site is known to display subthreshold oscillations at a particular frequency band, except the striatum which shows plateau depolarizations. Instead of a specific brain rhythm, the striatum may respond to overall brain activity, consistent with its possible role in pleasure principle: seek pleasure, avoid pain.

  • Alzheimer's disease: entorhinal cortex, theta band.
  • Parkinson's disease: subthalamic nucleus, beta band.
  • Amyotrophic lateral sclerosis: motor cortex, beta band.
  • Frontotemporal dementia: anterior cingulate cortex, alpha band.
  • Memory consolidation deficits: locus coeruleus, 0.3 - 3 Hz.
  • Motivational deficits: striatum, plateau depolarizations.

 

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