Geon mTOR, Tau and Neurodegeneration

 

Abstract

The mechanistic target of rapamycin (mTOR) is a protein kinase which, upon activation, triggers the synthesis of proteins, including the Tau protein. Hyperactive mTOR, thus Tau over-production, has been demonstrated to increase the risk for Alzheimer's disease and other neurodegenerative disorders. As discussed in Paper 2, excessive Tau proteins (especially the 4-repeat isoform) can cause hyperexcitability. Therefore, hyperactive mTOR should promote hyperexcitability. This novel mechanism is now well established. Since hyperexcitability is an early sign of neurodegeneration, the link among mTOR, Tau, hyperexcitability and neurodegeneration provides further evidence for the notion that neurodegeneration originates from hyperexcitability.

 

Read Online Download PDF