Home > Conscious > Chapter 6 > 6.2. G Protein-coupled Receptors

 

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Figure 6-2. A G protein-coupled receptor is characterized by seven transmembrane α helices. [Source: Wikipedia]

A G protein-coupled receptor (GPCR) is characterized by seven transmembrane α helices (Figure 6-2). It does not form an ion-conducting pore, but may act on ion channels via separated Gα or Gβγ, such as the activation of GIRK channels by Gβγ. In addition to ion channels, many effectors of the G-protein are enzymes. An example is illustrated in Figure 6-3 where the interaction between glutamate and mGluR targets PLC.

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Figure 6-3. The interaction between glutamate and mGluR can activate PLC. This process plays an important role in infra-slow oscillations (Figure 5-6). [Source: Wikipedia]